The schematic illustration of mutations distributed along the BRCA1 gene, as well as CIN status and TP53 copy loss within the 32 cases was shown in Fig. 3B. These results suggested that BRCA1 mutation profile may not impact the CIN status, whereas loss of TP53 function was associated with chromosome instability. The gene discussed is BRCA1; the disease is cervical squamous intraepithelial neoplasia.