AKT1 and neoplasm: To further investigate the role of curcumin in AKT/mTOR and autophagy, ACHN tumor cells were induced in C57BL/6 nude mice and treated with various concentrations of curcumin or 30 μM curcumin +3-MA, 15 μM curcumin + CQ or 15 μM curcumin+ Z-VAD.