The study aimed at assessing whether curcumin induces apoptosis of RCC and the involvement of AKT/mTOR pathway, the effects of curcumin on pro-inflammatory TNF-a, IL6 and IL-8 cytokines, and finally, to understand the role of curcumin in autophagy and tumor-growth in vivo. The gene discussed is TNF; the disease is renal cell carcinoma.