Genetically predicted elevated FAS (indicated by two FAS probes: FAS.9459.7.3 and FAS.5392.73.2) and THBS3 were associated with a higher risk of severe COVID-19 (OR [95% CI] per SD genetically predicted FAS concentrations indicated by FAS.9459.7.3: 1.38 [1.17, 1.62], p=1 × 10–4) and COVID-19 vs. lab/self-reported negative COVID-19 (OR [95% CI] per SD genetically predicted THBS3 concentrations: 1.70 [1.30, 2.22], p=9 × 10–5), respectively. Here, FAS is linked to COVID-19.