In this way, 25 new IDD-specific expression gene sets were determined, and 6 of these 25 genes, such as ACTB, HMOX1, JUN, MAPK1, SMAD3, TGFB1, have been reported to be associated with IDD, and there were 9 IDD-specific lncRNAs (GRAMD1B, PRKY, GRM2, DLEU1, TRIM69, ARMCX4, AC019205.1, DGCR5, AP002026.1). This evidence concerns the gene SMAD3 and intervertebral disk degenerative disorder.