LYL1 and nonpapillary renal cell carcinoma: Studies concerned about LYL1 mainly focused on lymphoblastic leukemia which indicated LYL1 acted as a oncogene in acute lymphoblastic leukemia and induced the development and progression of acute lymphoblastic leukemia65, 66, 67, 68, 69 and LYL1 has been demonstrated to regulate the early lymphoid differentiation of immature hematopoietic cells,70 which suggested it is possible for the association between immune infiltration and LYL1 in ccRCC.