The expression levels of hub gene across varied stages of ccRCC were compared, which showed CRYBB1 was significantly correlated with T stage (p‐value: 0.033), N stage (p‐value: 4.17e−03), and tumor grade (p‐value: 4.60e−05), RIMBP3C with T stage (p‐value: 0.034), and LYL1 with tumor grade (p‐value: 9.13e−04) (Figure 6B and Figure S2). This evidence concerns the gene CRYBB1 and nonpapillary renal cell carcinoma.