Next, immune‐related genes were derived by co‐expression network analysis and differential expression analysis, followed by the identification of five hub genes (CRYBB1, RIMBP3C, CEACAM4, HAMP, and LYL1) related to both sunitinib resistance and immune infiltration in ccRCC. This evidence concerns the gene CEACAM4 and nonpapillary renal cell carcinoma.