Log‐rank analysis further indicated CRYBB1 (HR: 1.56 [95% CI: 1.15−2.12]; p‐value: 3.67e−03), RIMBP3C (HR: 1.52 [95% CI: 1.12−2.07]; p‐value: 7.07e−03), CEACAM4 (HR: 1.54 [95% CI: 1.13−2.08]; p‐value: 5.46e−03), and HAMP (HR: 2.18 [95% CI: 1.58−3.00]; p‐value: 9.57e−07) were hazard factors to ccRCC with reference to OS in TCGA dataset (Figure 8A) and CRYBB1 (HR: 1.38 [95% CI: 1.00−1.88]; p‐value: 0.046), CEACAM4 (HR: 1.49 [95% CI: 1.08−2.04]; p‐value: 0.013), and HAMP (HR: 1.69 [95% CI: 1.23−2.33]; p‐value: 1.17e−03) were also involved in PFI of ccRCC (Figure 8A). This evidence concerns the gene CRYBB1 and nonpapillary renal cell carcinoma.