To further explore the potential mechanism of biological effect of H2 on myocardial infarction, we had set MCC950, the selective NLRP3 inflammasome inhibitor, as a positive control, which has therapeutic effects in a variety of disease models including diabetic arteriosclerotic bacterial inflammation, ischaemia reperfusion injury and so on.33 The gene discussed is NLRP3; the disease is myocardial infarction.