Our results demonstrated that hydrogen had similar therapeutic effect on cardiac remodelling and fibrosis induced by myocardial infarction as MCC950; however, MCC950 could not reduce oxidative stress indexes as hydrogen, which clearly explains the mechanism of hydrogen that regulate NLRP3 inflammasome by attenuating mitochondrial oxidative stress induced by mitochondrial damages. The gene discussed is NLRP3; the disease is myocardial infarction.