Western blot and qRT‐PCR data illustrated that H2 inhalation remarkably reduced the expression of NLRP3, IL‐1β, ASC, GSDMD'N and Caspase‐1 in myocardial tissue in contrast with MI group, and the therapeutic impact was similar to NLRP3 inhibitor MCC950 group. The gene discussed is GSDMD; the disease is myocardial infarction.