To our knowledge, our study provides for the first time a recommendations for the use of ddPCR analysis for adult BCR/ABL1+ ALL cases, showing that ddPCR allows to recover the quantifiability of MRD in a large proportion of patients, who otherwise would fall into a non‐quantifiable range of Q‐RT‐PCR, and launch the bases for using this approach also in Ph+ ALL. Here, BCR is linked to acute lymphoblastic leukemia.