Upon excellent glycemic control, bone loss was reduced in diabetic mice with peri-implantitis (DM+lig+BG control vs. DM+lig), whereas local injection with anti-RANKL antibody and miR146a showed no obvious effects on bone loss in peri-implantitis with uncontrolled diabetes (DM+lig+RANKL Ab+miR146a vs. DM+lig). This evidence concerns the gene TNFSF11 and diabetes mellitus.