Some of these strategies were topical administration of plasmid DNA coding for IFNα1 in the mouse eye to protect against HSV-1 encephalitis57, liposomic intranasal treatment using dsRNA to induce IFN58 as well as recombinant viral vectors such as adenoviruses59 and hepatitis B viruses to express type I IFN to protect against infection and tumor regression59. The gene discussed is IFNA1; the disease is neoplasm.