Antiphospholipid antibodies (lupus anticoagulant [LA], IgG and/or IgM anti-beta-2 glycoprotein-1 [aβ2GP1] and anticardiolipin antibodies [aCL]) that persist for more than 12-weeks, are well-recognised causes of venous, arterial, microvascular thrombosis and/or pregnancy morbidity; cardinal features of APS [5]. The gene discussed is CD40LG; the disease is autoimmune polyendocrinopathy.