A role for CHIP in membrane biology is of interest as membrane homeostasis has recently become a subject of investigation in α-synucleinopathies (Bozelli et al., 2021; Dettmer et al., 2017; Rovere et al., 2019) and, more generally, in neurodegenerative conditions (Bezprozvanny and Hiesinger, 2013; de Groot and Burgas, 2015; Marin, 2013). This evidence concerns the gene STUB1 and synucleinopathy.