STUB1 and tauopathy: Given the growing link between plasma membrane QC, membrane integrity and neurodegeneration (Naudí et al., 2013; Shrivastava et al., 2017; Wong-Ekkabut et al., 2007; Zhao et al., 2013), as well as cytoskeletal defects and neurodegeneration (e.g. tauopathies) (Bamburg and Bloom, 2009), understanding how CHIP influences both the cytoskeleton and plasma membrane integrity could provide insights into disease mechanisms.