IL18RAP effectively inhibits the growth of HCC cells by inhibiting angiogenesis and apoptosis signal transduction involving caspase-3, which fully demonstrates the antitumor effect of IL18RAP. 37In our study, we divided HCC patients into two groups based on the five DEIC-based classification in TCGA and LIRI_JP, and verified the accuracy and reliability of the classification. The gene discussed is CASP3; the disease is hepatocellular carcinoma.