In addition, it was demonstrated that sulforaphane, which induces Trx protein, has protective effects on diet‐induced metabolic syndrome and diabetes (Lv et al., 2020; Tanito et al., 2005; Tian et al., 2021), whereas the effects of exogenous hTrx‐1 on genetically severe diabetes are unknown. This evidence concerns the gene KMT2A and metabolic syndrome.