CREB1 and infection: Chronic morphine treatment was found to change the expression of FBJ osteosarcoma oncogene (FOS) and cAMP-responsive element-binding protein 1 (CREB1), cAMP-responsive element modulator (CREM) (13) in the striatum and nucleus accumbens (13) it also increases the degeneration tissue, cytokines, stress signals such as free oxygen radicals (14), mitogenic stimulation (15), infections, and oncogenic compounds (16) and oxidative stress (17); also, it decreases growth factor in the various organs of rats (18).