According to the data shown by the String database, there is an interaction between FOS with Interleukins receptor, apoptosis-related cysteine peptidase (CASP1), Mitogen-activated protein kinase 14 (MAPK14), Jun proto-oncogene (JUN), and FBJ murine (42); in addition, according to another study, in evaluating specific types of male infertility, Interleukins and FOS in seminal plasma should be extended; Thus, the changed FOS influences the innate immunity level in male infertility (43). This evidence concerns the gene FOS and male infertility.