Antioxidant effect of atorvastatin in diabetes may be mediated through inhibition of Rac-1 and geranylgeranyl pyrophosphate (GGPP), induction of heme oxygenase, interference with NAD(P)H oxidase expression and activity and antagonization of the pro-oxidant effect of angiotensin II (47-49, 15). This evidence concerns the gene FMO5 and diabetes mellitus.