Based on the identified transcriptome changes associated with the scRNA-seq findings and the gene function reported in fibrotic diseases, we hypothesized that, following environmentally triggered inflammation, salivary gland immune cells produce pro-inflammatory cytokines associated with SS (e.g., TNF-α and interferon) that activate salivary gland epithelial, endothelial and myoepithelial cells and overexpress genes such as TGFB2, WNT4, and BMP3, which are key inducers of EMT. The gene discussed is TNF; the disease is synovial sarcoma.