Litjens et al. recently reported that donor-derived memory-like NKG2C+ natural killer cells and Vδ2negγδ T lymphocytes could be expanded by CMV replication, and the terminally differentiated TCR αβ+ T lymphocytes with poor alloimmunity, NKG2C gene expression, and resistance of the adaptive immune system driven by interferon could be enhanced during CMV infection 51. Here, KLRC2 is linked to cytomegalovirus infection.