NLRP3 and myocardial ischemia: 35 Inflammation in myocardial infarction occurs in the absence of infectious agents and is therefore known as “sterile inflammation”. 36 This is mediated through the NLRP3 inflammasome. Inhibition of this inflammasome reduces infarct size and preserves cardiac function in a pig model of I/R injury.37 The generation of ROS is one of the upstream pathways of NLRP3 inflammasome activation. 21 In view of the antioxidant properties of hydrogen, we hypothesize that it can reduce the oxidative stress caused by myocardial ischemia in rats.