CD4 and neoplasm: In recent years, tumor-cell derived autophagosomes (DRibbles), which enriched in long-lived proteins, short-lived proteins, and DRiPs after inhibition of proteasome and lysosome function, has demonstrated efficient cross-priming antigen-specific naïve CD4+ and CD8+ T-cells in vitro and in vivo; and DRibbles-based DC vaccine has shown high efficiency in inducing antitumor immune responses in immunodeficient mice models 16, 23, 27, 28.