Furthermore, by incubating immature BMDCs with DRibbles and lysates, CCSC-derived DRibbles significantly induced the upregulation of MHC-I molecules compared to other groups, suggesting a stronger capability of CCSC-derived DRibbles in inducing efficient cross-priming of tumor-specific CTLs and activating naïve CD8+ T cells. The gene discussed is CD8A; the disease is neoplasm.