According to Forel et al., the number of NK cells (CD56+CD3-) in blood samples collected from patients in the ICU is significantly reduced during all stages of sepsis and shows indiscriminate features such as degranulation, as indicated by CD107 or LAMP-1 (lysosomal-associated membrane protein-1) expression and decreased cytotoxicity compared to NK cells from healthy controls 127. The gene discussed is NCAM1; the disease is Sepsis.