PTEN and cholesteatoma of middle ear: The Western blotting results are revealed in Fig. 6B and 6C. Compared with those in miR-508-3p NC group, the level of PTEN protein in middle ear cholesteatoma cells decreased in miR-508-3p mimic group and increased in miR-508-3p inhibitor group (p<0.05), while the levels of PI3K and p-Akt proteins raised in miR-508-3p mimic group (p<0.01, p<0.001) and lowered in miR-508-3p inhibitor group (p<0.001, p<0.001).