The results of ELISA are shown in Fig. 5B and 5C. Compared with those in miR-508-3p NC group, Bax level in middle ear cholesteatoma cells was decreased in miR-508-3p mimic group(p<0.05) and enhanced in miR-508-3p inhibitor group (p<0.01) respectively, while Bcl-2 level was elevated in miR-508-3p mimic group (p<0.01) and declined in miR-508-3p inhibitor group (p<0.01) respectively. Here, BCL2 is linked to cholesteatoma of middle ear.