The result that rAd-p53 + PTX significantly inhibited PTC tumor in vitro and in vivo through p53-dependent apoptosis response to DNA damage suggested activation of p53 had a great meaning for the clinical management and treatment of PTC and rAd-p53 combined with chemotherapy, which might be used in the treatment of advanced-stage PTC patients with tumors unsuitable for surgery. This evidence concerns the gene TP53 and neoplasm.