CD274 and familial pancreatic carcinoma: Although this study provides clues and basis for in-depth discussion of the role of PD-L1 gene in pancreatic cancer, the occurrence and development of tumor is a complex regulatory process coordinated by multiple genes, and the specific mechanism of PD-L1 gene's involvement in the development of pancreatic cancer through the above pathways remains to be further clarified by follow-up studies.