The therapeutic potential of ALLO to rescue cerebellar WM and behavioral abnormalities was then tested by administering ALLO (10 mg kg−1) or vehicle (sesame oil) to dams carrying mixed litters at E15.5, the period of maximal difference of ALLO levels in the plKO mice compared to C. A single injection of ALLO during gestation prevented the cerebellar MBP up-regulation (Fig. 4a), normalized OL density in the cerebellar WM (Extended Data Fig. 10a) and reduced the autism severity score (Fig. 4b,c). The gene discussed is MBP; the disease is autism.