For example, PRIM2, DOCK4, and DARS can be modulated by STAT family proteins; COL22A1, NGDN, and UNC5b by GATA family proteins; and DNAH11 by aryl hydrocarbon receptor and translocator, which induce somatotroph tumor formation (www.genecards.org). The gene discussed is PRIM2; the disease is neoplasm.