Regarding kinase activity, MAST4, TNN, PLXND1, and COL22A1 are directly involved in the serine/threonine kinase family and PI3K-Akt and Akt signaling pathways, which can induce tumor formation in GH-secreting pituitary adenoma (www.genecards.org)23–25. The gene discussed is COL22A1; the disease is neoplasm.