KAT2B and neoplasm: There were also two independent seeding events from the primary tumor, one giving rise to a lung metastasis with variants in KAT2B, CAMK1D, and SLC16A, and the other giving rise to a liver metastasis with a subclonal KRASG12V variant which expanded to ~100% CCF in 6 downstream metastases that arose shortly before the patient’s death (Fig. 2d).