C1S and neoplasm: The amplification of genes such as COL5A1, IDO1, and GOLIM4 were in accordance with their higher expression in tumor samples (Supplementary Fig. 3h, i), whereas no significant change of protein or phosphorylation levels was observed for genes with genomic amplification, such as CD4, CD7, LIME1, UNC93B1, C1S, C1R, or C8G.