The downregulation of many of these proteins such as ITGA738,39, TIMP340,41, ABI3BP42, MYLK, and MYL943 (Supplementary Fig. 4d), have been reported to be associated with proliferation, invasion, and migration in various types of cancers—suggesting that this might serve as a potential mechanism underlying the malignant S2 subtype. The gene discussed is MYLK; the disease is cancer.