On the contrary, knockdown of MAST1 abolished cisplatin-resistant cancer cell proliferation, tumor growth, and MEK-ERK phosphorylation obtained by enforced GR expression or activation in vitro (Fig. 7f, g; Supplementary Fig. 6d, e) and in vivo (Fig. 7h–j; Supplementary Fig. 6f). Here, MAP2K7 is linked to cancer.