ERBB2 and breast cancer: Unlike most other AARSs, SerRS mRNA level has been shown to positively correlate with the survival of breast cancer patients, suggesting a tumor suppressor role of SerRS beyond protein translation in the cytoplasm.23 We therefore analyzed the SerRS protein level in eleven human breast cancer tissues, which includes the intrinsic subtypes of luminal A and B, HER2 + and TNBC.