Metabolically stressed cancer cells can also utilize exogenous acetate to generate acetyl-CoA by acyl-CoA synthetase short chain family member 1 and 2 (ACSS1 and ACSS2).11,12 Upregulation of key genes involved in de novo FA synthesis and lipid metabolism has been well demonstrated to be a metabolic feature of cancer cells.2 The gene discussed is ACSS1; the disease is cancer.