Importantly, we detected higher level of FOSL1 mRNA in the cohort of IDH-wt gliomas with NF1 alterations (Student’s t test p=0.018) (Figure 2C), as well as a significant negative correlation between FOSL1 and NF1 mRNA levels (Pearson R = −0.44, p=7.8e-12) (Figure 2D and Supplementary file 4). The gene discussed is IDH1; the disease is central nervous system cancer.