In breast cancer cells, FOSL1 expression correlates with mesenchymal features and drives cancer stem cells (Tam et al., 2013) and the regulation of EMT seems to happen through the direct binding of FRA-1 to promoters of EMT genes such as Tgfb1, Zeb1, and Zeb2 (Bakiri et al., 2015). This evidence concerns the gene ZEB1 and breast cancer.