IDH1 and central nervous system cancer: Consistent with the negative correlation of FOSL1 and NF1 mRNA levels in IDH-wt gliomas (Figure 2D), NF1-GRD overexpression in two independent MES GBM lines (BTSC 233 and BTSC 232) was associated with a significative downregulation of FOSL1 and FOSL1-regulated genes (Figure 2E and Figure 2—figure supplement 2A–C).