Concurrently, we also observed a significant decrease of two well-characterized mesenchymal features, namely CHI3L1 expression (Figure 2F) as well as the ability of MES GBM cells to differentiate into osteocytes, a feature shared with mesenchymal stem cells (Ricci-Vitiani et al., 2008; Tso et al., 2006; Figure 2—figure supplement 2D). Here, CHI3L1 is linked to glioblastoma.