TNF and obesity due to melanocortin 4 receptor deficiency: On the other hand, studies have shown that following pro-inflammatory diets raises the levels of many inflammatory markers, including; Tumor necrosis factor alpha (TNFα), high-sensitivity C-reactive protein (hs-CRP), Interleukin1beta (IL-1β), Interleukin 6 (IL-6), Interleukin 10 (IL-10), in obese or chronically ill people, especially in women, which in turn has led to the spread of obesity in these people [13, 20, 21].