We tracked tumor engraftment and progression via BLI and show that TOFA treatment reduced T-ALL disease burden (Fig. 5A), delayed tumor progression in established subcutaneous tumors in all three MYC-, RAS-, and BCR-ABL-driven cell lines, and substantially abrogate tumor progression in the primary model of MYC-driven T-ALL mice even after treatment regimens had halted (Fig. 5C). This evidence concerns the gene ABL1 and acute lymphoblastic leukemia.