Examples of predicted open chromatin interactions are shown at important CLL prognostic markers, such as LPL (Fig. 7g), ZAP70 (Additional file 1: Fig. S11f), ZNF667 (Additional file 1: Fig. S11g), and CD38 (Additional file 1: Fig. S11h) [45–48]. The gene discussed is CD38; the disease is B-cell chronic lymphocytic leukemia.