Moreover, the first convolutional layers of all CLL models were able to capture the CTCF and AP-1 transcription family member (FOS, JUN, JUNB, JUND) binding motif (Additional file 1: Fig. S9c), similar to the Hi-C models we showed earlier (Additional file 1: Fig. S4e; Additional file 1: Table S4-5). Here, JUNB is linked to B-cell chronic lymphocytic leukemia.