CTCF and B-cell chronic lymphocytic leukemia: RNA Pol II-associated chromatin interactions were better conserved across the CLL samples than CTCF-associated chromatin interactions (Fig. 7b), which could be attributed to that open chromatin regions in the CLL samples that overlapped with GM12878 RNA Pol II peaks were better conserved than those overlapping with GM12878 CTCF peaks (Fig. 7c).