ERBB2 and neoplasm: Briefly, small tumor size [7], high grade [8], high Ki67 expression [9]], and high sTILs [12–14] are positively related to pCR in NAC settings, while hormone receptor-positive (HR +) or human epidermal growth factor receptor 2-negative (HER2 −) subtypes have lower pCR rates than HR- or HER2 + subtypes [10, 11].