Furthermore, the model with random effect also showed CRF55_01B infections were 1.2 log10 copies/ml/year higher increasing rate of viral load than CRF07_BC infections after adjustment for age at diagnosis, ethnicity, marital status, and year of HIV diagnosis, although not significantly different for the group with initial CD4 count as 350cells/μl or above. This evidence concerns the gene CD4 and infection.