Among the 1792 MSM who were infected with the three main subtypes, CRF55_01B-infected MSM showed a significantly lower median CD4 count than CRF07_BC-infected MSM at diagnosis of HIV infection (349.5 [IQR, 250.2–474.8] vs. 370.0 [IQR, 278.0–501.0], P < 0.05), as well as at initiation of cART (224.0 [IQR, 165.2–283.0] vs. 265.0 [IQR, 198.0–348.0], P < 0.01) (Fig. 2). This evidence concerns the gene CD4 and HIV infectious disease.