In a study comparing 113 gastric cancer patients (24 with the ACE II allele and 32 with the DD genotye) and 189 controls with no gastric cancer, a significantly higher number of lymph node metastases (p < 0.001) and higher Unio Internationale Contra Cancrum (UICC) tumor stage (p = 0.01) were associated with the DD genotype as compared with the II allele. This evidence concerns the gene ACE and gastric cancer.