ACE2 and COVID-19: Analyzing 349 worldwide population samples from Allele Frequency Database (ALFRED), ID and DD ACE polymorphisms were found to be associated with enhanced ACE/Ang-II activity, increased blood pressure and severe acute respiratory distress syndrome among COVID-19 patients as compared with other genotypes [86] As already mentioned, ACE-2 polymorphism can be more common in some GI cancers and can also promote malignant mutations.