ACE and cancer: For instance, in a Chinese study contrasting 241 colorectal cancer patients with 299 non-cancer controls enrolled from April 2008 to October 2010, those carrying the ACE D allele were more likely to develop undifferentiated tumors (OR = 1.54; 95%CI: 1.04–2.28) and metastasis (OR = 1.56; 95%CI: 1.08–2.26) as compared to those carrying the ACE I genotype, although there was no remarkable correlation among cases and controls [87].