Many key genetic changes, including the amplification of c-Myc, fusion of TMPRSS2 and ETS family genes, amplification and/or mutation of the androgen receptor, deletion and/or mutation of PTEN and TP53, and mutation of SPOP (speckle type BTB/POZ protein) have been reported to contribute to the development and progression of PCa [3]. Here, SPOP is linked to posterior cortical atrophy.