TP53 and squamous cell carcinoma: In another study by Grace et al., a significant positive correlation was observed between HPV-induced squamous cell carcinoma (SCC) and the expression levels of Bcl2/p53 proteins [57] suggesting that the high-risk HPV-E6 oncoprotein could enhance the Bcl-2 protein expression through the blocking of the inhibitory activity of p53 on Bcl-2 [58].