In comparing inflammetory factors between HPV/EBV co-infection PCa group with mono EBV infected PCa group, it was observed that there was a significant higher mean expression level of TNF-α, IL-17, IL-8, RNS, ROS, TGF-β and VEGF in coinfected group than in the mono EBV infected group, but the two groups showed no significant difference in the mean expression level of IL-11, IL-6, IL-1 and NF-κB (P > 0.05). This evidence concerns the gene CXCL8 and posterior cortical atrophy.