Mutations in the PRPH2 gene result in degeneration in both central and peripheral retina, and lead to a variety of retinal degenerative diseases, such as RP [6], macular and cone/cone-rod dystrophies [8], foveomacular vitelliform dystrophy [9], central areolar choroidal dystrophy, and other forms of late-onset macular degeneration [10]. Here, PRPH2 is linked to retinitis pigmentosa 1.