IFNG and infection: Since bacteria of the Burkholderia genus employ different routes of infection (subcutaneous infection, inhalation, ingestion of contaminated particles, and aerosol) (1), we tested if IFN-γ priming restricts MNGC formation in human cell lines that are physiologically more relevant for Burkholderia-induced melioidosis, such as HBEC3-KT cells (human bronchial epithelial cells), HaCaT cells (human keratinocytes), and human primary monocyte-derived macrophages (hMDMs).