STOX2, LIMD1, RBMS1, KCNQ4, GNPTAB, HMGA1, SCD, IGF2BP2, STK40, FOXP2, and UTRN were downregulated, whereas FIGN, FRMD4B, PRPF38B, IGF2BP3, STARD3NL, SOCS4, C5orf51, TMPPE, E2F6, and FNDC3A were upregulated in patients with β‐thalassemia. The gene discussed is SOCS4; the disease is thalassemia.