Moreover, neither MMP-9 (44 ± 44 vs. 33 ± 12 ng/mL, P = 0.62), APP770 (81 ± 32 vs. 93 ± 8 ng/mL, P = 0.44), endothelin-1 (6.3 ± 23.7 vs. 0.4 ± 0.6 pg/mL, P = 0.62), S100B (13 ± 39 vs. 14 ± 20 pg/mL, P = 0.96), nor claudin-5 (1.7 ± 2.2 vs. 1.5 ± 1.1 ng/mL, P = 0.82) levels were associated with parenchymal hematoma. Here, EDN1 is linked to parenchymal hematoma.