POLR3A and metastatic malignant neoplasm in the lymph nodes: In bladder cancer, RNA polymerase III (POLR3A) promotes the proliferation of bladder cancer cells by inhibiting their differentiation; in colorectal cancer, POLR3A is expressed at high levels and is associated with advanced tumor depth, lymph node metastasis, distant metastasis, and poor prognosis [37, 38].