In recent years, research studies based on the mRNA characteristic (such as alpha-fetoprotein in liver cancer and prostate-specific antigen in prostate cancer, and so on) for predicting the mortality risk of cancer has become a new hotspot for researchers, but so far, none of these studies were able to identify reliable indicators for the prediction of CRC prognosis [28]. Here, KLK3 is linked to Familial prostate cancer.