Importantly, as observed in mouse tumors (Fig 2), mutations in the orthologs KMT2C (MLL3), ARID1B (BAF250B), NCOA2 (KAT13C), and CREBBP (CBP/KAT3A) were also found in the same cuSCC genomes harboring ZMIZ mutations (Fig 4), suggesting they might cooperate during human keratinocyte transformation or tumor progression. Here, KMT2C is linked to neoplasm.