In conclusion, our present findings indicated that the inhibition of glutathione synthesis by repeated treatment with BSO alone and together with GBR 12909 in early postnatal development induced long-term deficits corresponding to schizophrenia-like behavior evaluated in the social interaction and novel object recognition tests, and decreased the expression of BDNF mRNA in the frontal cortex and hippocampus. This evidence concerns the gene BDNF and schizophrenia.