The discovery of remarkably smaller cerebral infarcts size in Nox2-deficient mice subjected to MCAO and considerably lower oxidative stress level after knockdown of Nox-2 activity in neuronal cells exposed to hyperglycaemia with ischaemic damage corroborate the therapeutic benefits of Nox2 inhibition during hyperglycaemic injury (Kahles et al. 2007; Zeng et al. 2018) Figs. 8–10. Here, CYBB is linked to Hyperglycemia.