ADIPOQ and Insulin resistance: Additionally, compared with full-length adiponectin, gAd, a globular domain of full-length adiponectin, is more effective in improving insulin resistance and increasing fatty acid oxidation (Yamauchi et al. 2001; Berg et al. 2001; Fruebis et al. 2001; Yamauchi et al. 2002; Goldfine and Kahn 2003).