Based on electrochemical measurement, Liu et al. developed a new aptasensor for immobilizing epidermal growth factor receptor (EGFR)-targeting aptamer strands on a porphyrin COF (p-COF), which can sensitively and selectively bind to EGFR to detect human breast cancer MCF-7 cells (Fig. 7a) [106]. This evidence concerns the gene EGFR and breast cancer.