Similarly, fluoxetine, a selective serotonin reuptake inhibitor with anti-inflammatory properties, although showing promising neuroprotective results in MBP-α-Syn mice, failed to change the disease progression in a double-blind phase II clinical trial in MSA patients (NCT01146548) (Ubhi et al. 2012; Valera et al. 2014). The gene discussed is MBP; the disease is multiple system atrophy.