It is particularly important to investigate effects of eIF4A inhibition on BCR responses in CLL, since BCR signaling itself has a profound impact on the translation machinery [22] and BCR signaling strongly increases expression of MCL1 (and MYC) [19, 21, 22] and could, therefore, influence susceptibility to eIF4Ai-mediated inhibition. This evidence concerns the gene BCR and B-cell chronic lymphocytic leukemia.