CLL cells were pretreated with silvestrol or DMSO for 1 h and then exposed to control antibody or anti-IgM, we used silvestrol at 20 nM as this concentration resulted in significant accumulation in MYC mRNA, with only a small decrease (17%) in cell viability (Fig. 1C). The gene discussed is CD40LG; the disease is B-cell chronic lymphocytic leukemia.