We previously showed that stimulation of RNA translation following BCR activation on CLL cells was associated with profound reprogramming of the translational machinery, including increased expression of two core components of eIF4F, a complex that is recruited to the 5ʹ m7G cap, containing several components including; eIF4A, and the scaffold protein, eIF4G [22]. Here, BCR is linked to B-cell chronic lymphocytic leukemia.