This project focused on the impact of eIF4Ai in CLL cells, therefore, we compared our primary samples to sIgM naïve (CD27−) or non-switched IgM memory (CD27+) B cells, that are predicted to be the cell of origin for unmutated (U) or mutated (M) CLL, respectively. The gene discussed is EIF4A1; the disease is B-cell chronic lymphocytic leukemia.